Magnesium sulfate is the most widely used preparation of magnesium salt in clinical practice.
Magnesium sulfate injection can be used as an anticonvulsant. It is often used for gestational hypertension, lowering blood pressure, treatment of preeclampsia and eclampsia, and treatment of premature delivery.
Not only that, magnesium acid is also a second-line drug for the treatment of acute asthma attacks. It has been more than 80 years since magnesium sulfate was first used for asthma in 1936.
The dosage of magnesium sulfate
In studies of acute episodes of asthma in adults, most patients were given intravenous magnesium sulfate (1.2-2.0g).
Intravenous administration of magnesium sulfate in children with acute asthma attacks has a wide range of doses, 25-100 mg/kg, with a maximum dose not exceeding 2g.
The British thoracic society recommends the use of 1.2-2.0g intravenous magnesium sulfate in adults with severe acute asthma attacks, with infusion time greater than 20min.
The recommended dose for children is 40mg/kg for at least 20min.
It has also been reported that the dose range of inhaled magnesium sulfate is 125-500mg. In order to avoid the occurrence of bronchoscopies caused by hyperosmolar status of inhalant, it is recommended that the cumulative dose per inhalation should not exceed 500mg.
The 2017 GINA guide notes that inhaled aerosolized magnesium sulfate is primarily used as an additional treatment for acute episodes of severe asthma in which conventional bronchodiastolic agents are not effective.
In general, 150 mg of magnesium sulfate isosmosis is inhaled for each dose, which can be used for 3 times within the first hour of the initial treatment. It is only suitable for the additional treatment of critical asthma attack in children aged ≥2 years old, especially for the duration of the attack < 6 hours.
Studies have found that, when the acute attack of asthma occurs, the serum magnesium ion concentration of some patients is low and negatively correlated with the severity of asthma, that is, the more severe the asthma symptoms are, the lower the serum magnesium ion concentration will be, and the serum magnesium ion concentration of patients will increase appropriately after treatment.
In recent years, studies have found that oral magnesium supplementation can improve the serum magnesium ion level of patients with asthma, and may be helpful in the control of asthma symptoms.
It can be speculated that long-term oral administration of magnesium may prevent the acute onset of asthma in patients with stable asthma, especially in the presence of hypomagnesemia, but this needs to be further demonstrated.
In summary, magnesium sulfate is used in a wide range of doses in the treatment of asthma, perhaps because there is no uniform dose range, the treatment effect of magnesium sulfate is inconsistent.
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Mei shen has a high-level sales team. The business covers more than 20 countries and regions around the world. It is widely welcomed by new and old customers.